The Effect Of Administering Herbal Extract Of Sambiloto Leaves (Andrographis Paniculata) On Blood Sugar Levels In Male White Rats (Rattus Norvegicus) Induced By Aloksan

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Abstract

Introduction: Diabetes mellitus is a chronic disease characterized by hyperglycemia, namely high levels of sugar in the blood. This condition occurs due to a disruption in the production or function of insulin in the body , or both. Currently, people prefer alternative treatments using herbal medicines because they have few side effects and are easy to obtain both in terms of price and availability. Sambiloto (Andrographis paniculata Ness) is a traditional medicine used by Indonesians to lower blood glucose because it contains andrographolide and flavonoids.

Objectives and Methods: This study aims to determine whether bitter leaf herbal extract has an anti-diabetic effect on male diabetic white rats (Rattus norvegicus). This study used a pretest-posttest control group design. The ingredient used is bitter leaf extract. Subjects were 25 mice divided into five groups, namely P1 (Na-CMC 0.5%), P2 (metformin 45 mg/kgBB), P3 (extract 100 mg/kgBB), P4 (extract 200 mg/kgBB), and P5 (400 mg/kgBB extract).

Results: One Way ANOVA test showed significant differences in the five treatment groups with p = 0.000 (p<0.05). The LSD post hoc test showed that there was a significant difference between P3 and P1, P2, and P5 and not significantly different from P4.

Conclusions: Based on research results, bitter leaf extract (Andrographis panicula) 400 mg/kgBB can significantly reduce blood glucose levels in male rats (Rattus norvegicus)